Are you struggling with sticking powders, inconsistent flow, or moisture-sensitive formulations? These challenges can disrupt tablet production, leading to inefficiencies, stability issues, and regulatory hurdles. But there's a simple yet powerful solution: Colloidal Silicon Dioxide (CSD).
Formulating tablets with challenging APIs means facing:
- Sticking to punches & dies during compression → Leads to defects and downtime.
- Poor powder flow → Causes weight variation and inefficiency.
- Moisture sensitivity → Threatens stability and shelf life.
These issues can jeopardize product quality, production speed, and regulatory compliance.
The Solution: Colloidal Silicon Dioxide (CSD)
This multifunctional excipient enhances formulation efficiency by acting as:
- Anti-Adherent – Prevents sticking, reducing equipment cleaning time.
- Glidant – Enhances powder flow for consistent tablet weight.
- Moisture Barrier – Protects hygroscopic APIs, ensuring stability.
Key Benefits
- Minimized production delays – Reduces frequent equipment cleaning.
- Extended shelf life – Ensures stability in harsh conditions.
- Reliable drug release – Supports patient safety and efficacy.
- Cost-efficient manufacturing – Optimizes yield and reduces waste.
How to Optimize Its Use?
- Fine-tune concentration – Typically 0.5–5% (w/w) for optimal performance.
- Pre-Granulation Strategy – Blend API with CSD (0.5–5% w/w ), then add other excipients intra-granularly.
- Strategic Combinations – Works well with hydrophilic binders (e.g., HPMC) for enhanced moisture protection.
Read also: Common Tablet Defects and Remedies
Resource Person: Jamal Jameel
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