Pharmacy Courses

Scale-Up Factor for Blender

1) GEOMETRIC SIMILARITY

Keeping the ratio of all lengths constant (constant fill ratio).

FILL RATIO: is defined as the ratio of Bed height and Diameter (H/D ratio)

H/D Ratio (Constant fill ratio) = Powder bed height (cm)/(Blender diameter (m) x 100)

Powder Bed height (cm) = (Dry mix volume (L) x 1000) / Total volume of Blender (L)

Total Volume of Blender = ¼ π D^2
Bed height (cm) = Dry mix volume (L) X 1000 / ¼ π D^2 X 10000
Bed height (cm) = 4 X Dry mix volume (L) X 1000 / π D^2 X 10000

Where,
  • D = Diameter of Blender in meter
  • π = 3.14

Note: Blender diameter = Available from equipment manual or qualification document.

2) DYNAMIC SIMILARITY

Maintaining constant forces.

Froude Number

Froude Number: N^2 R/g

Where,
  • N - Rotation RPM
  • R –Vessel Radius
  • g – Gravitation Constant

3) KINEMATIC SIMILARITY

Maintaining a consistent number of revolutions (rpm × minutes).

  • 50 L Blender : 15 RPM*10 minutes: 150 revolution
  • 250 L Blender : 10 rpm* 15 minutes : 150 revolution

To Keep Froude Number same from Demo to Exhibit to Commercial scale, we have to change the variable i.e Rotation RPM.


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