QTPP, CMA, CPP and CQA of Liquid Dosage Form

Quality Target Product Profile (QTTP) of Liquid Dosage Form

• Dosage Form
• Route of administration
• Dosage Strength
• Pharmacokinetics

Physical  

• Appearance/Description
• Weight/Volume
• Viscosity
• Container content/Net content
• pH

Chemical

• Impurities
• Content uniformity
• Assay

Packaging and storage 

• Container closure system
• Storage condition
• Shelf life
• Others (If required)

Critical Material Attributes (CMA) of Liquid Dosage Form

• Particle size
• Solubility
• Water content

Critical Process Parameter (CPP) of Liquid Dosage Form

• Order of material addition
• Mixing time
• Mixing speed
• Mixing temperature
• Homogenization speed

Critical Quality Attributes (CQA) of Liquid Dosage Form

• Description/Appearance
• Weight/Volume
• Water content
• Viscosity
• pH
• Assay
• Impurities
• Dissolution
• Uniformity of dosage unit
• Microbial limits
• Others (if required)

Read also:

• CPP and CQA in Tablet Manufacturing
  
• CPP and CQA in Capsule Manufacturing