LOD and Water content are two important parameters for pharmaceutical raw materials. The stability of a material depends on its LOD and Water content.
LOD vs. Water Content
- Water content is determined by the Karl Fischer titration method.
- Loss on drying (LOD) is determined by heating the sample below its melting point in an oven.
- Water content consists of only water i.e moisture content.
- LOD includes all volatile matter including water content and solvents.
- LOD is generally higher than water content.
Difference Between Water Content and Moisture Content
- Water content refers to wet basis.
- Moisture content refers to a dry basis.
- Water content measured by = (total weight - dry weight)/total weight.
- Moisture content measured by = (total weight - dry weight)/dry weight.